Dipeptidyl-Peptidase IV-beta, a Novel form of Cell-Surface-Expressed Protein with Dipeptidyl-Peptidase IV Activity

Targeting Dipeptidyl Peptidase IV (CD26)

Tackling dipeptidyl peptidase IV in neurological disorders

Dipeptidyl peptidase IV (DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1 (GLP-1), pituitary adenylate cyclase-activating polypeptide (PACAP) and glucose-dependent insulinotropic peptide (GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inh...

Dipeptidyl Peptidase IV and Incident Diabetes

OBJECTIVE Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. RESEARCH DESIGN AND METHODS Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 ye...

Dipeptidyl-Peptidase IV Activity Is Correlated with Colorectal Cancer Prognosis

BACKGROUND Dipeptidyl-peptidase IV (EC 3.4.14.5) (DPPIV) is a serine peptidase involved in cell differentiation, adhesion, immune modulation and apoptosis, functions that control neoplastic transformation. Previous studies have demonstrated altered expression and activity of tissue and circulating DPPIV in several cancers and proposed its potential usefulness for early diagnosis in colorectal c...

Cd26/Dipeptidyl Peptidase IV in Context

C D26, the T cell activation molecule, is a 110-kD gly-coprotein that is also present on epithelial cells of various tissues, including the liver, kidney, and intestine. CD26 possesses a known dipeptidyl peptidase (DPP)IV activity in its extracellular domain (1). A paper by Wesley et al. in this issue indicates a possible role for CD26/DPPIV in suppressing malignant transformation of melanocyte...